Article
Metastatic human hepatoblastoma cells exhibit enhanced tumorigenicity, invasiveness and a stem cell-like phenotype.
Journal of pediatric surgery - 1 Jun 2022
Marayati Raoud, Julson Janet R, Bownes Laura V, Quinn Colin H, Hutchins Sara C, Williams Adele P, Markert Hooper R, Beierle Andee M, Stewart Jerry E, Hjelmeland Anita B, Mroczek-Musulman Elizabeth, Beierle Elizabeth A
Abstract excerpt
BACKGROUND/PURPOSE: Metastatic hepatoblastoma continues to pose a significant treatment challenge, primarily because the precise mechanisms involved in metastasis are not fully understood, making cell lines and preclinical models that depict the progression of disease and metastasis-related biology paramount. We aimed to generate and characterize a metastatic hepatoblastoma cell line to create a model for...
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