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Article

A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis

18 Feb 2022

Abstract excerpt

Abstract Background and Aims Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigate whether the neonatal liver provides a protumorigenic niche to HB development. Approach and Results HB development was compared between orthotopic transplantation models established in postnatal day 5 (P5) and 60 (P60) mice (P5 Tx and P60 Tx models)....

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PMID: 35179799
DOI: 10.1002/hep.32412

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