Article

Clonal determinants of organotropism and survival in metastatic uveal melanoma

2024-05-15

Abstract excerpt

Uveal melanoma (UM), the most common intraocular primary cancer in adults, demonstrates a unique proclivity for liver metastasis. To understand the molecular underpinnings of this organotropism, we analyzed the genomic features of liver and extrahepatic UM metastases, identifying distinct molecular signatures that mirror the clonal diversity in primary UM tumors. Liver metastases were enriched in BAP1 mutations a...

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Literature Corpus work: ae95735b-adf7-5e42-b264-b0797eacaa95
DOI: 10.1101/2024.05.14.593919

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