Article

CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seeding

2026-04-19

Abstract excerpt

Small cell lung cancer (SCLC) is a highly metastatic malignancy with tropism to the liver, yet the signals that enable organ-specific metastatic colonization remain largely undefined. During metastasis, disseminated cancer cells first encounter endothelial cells (ECs) at the vascular-tissue interface, positioning cancer-endothelium crosstalk as a key determinant of metastatic success. Defining the signaling pathwa...

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Literature Corpus work: 3d2a0f80-f1f2-55dc-8a02-bfc1e2617f6e
DOI: 10.64898/2026.04.15.716394

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