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Article

Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2020

Sui Yang, Qi Lei, Zhang Ke, Saini Natalie, Klimczak Leszek J, Sakofsky Cynthia J, Gordenin Dmitry A, Petes Thomas D, Zheng Dao-Qiong

Abstract excerpt

Yeast strains with low levels of the replicative DNA polymerases (alpha, delta, and epsilon) have high levels of chromosome deletions, duplications, and translocations. By examining the patterns of mutations induced in strains with low levels of DNA polymerase by the human protein APOBEC3B (a protein that deaminates cytosine in single-stranded DNA), we show dramatically elevated amounts of single-stranded DNA...

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Identifiers

PMID: 32277034
DOI: 10.1073/pnas.1922472117
PMCID: PMC7196835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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