Article
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.
The EMBO journal - 15 Feb 2012
Davidson Marta B, Katou Yuki, Keszthelyi Andrea, Sing Tina L, Xia Tian, Ou Jiongwen, Vaisica Jessica A, Thevakumaran Neroshan, Marjavaara Lisette, Myers Chad L, Chabes Andrei, Shirahige Katsuhiko, Brown Grant W
Abstract excerpt
The integrity of the genome depends on diverse pathways that regulate DNA metabolism. Defects in these pathways result in genome instability, a hallmark of cancer. Deletion of ELG1 in budding yeast, when combined with hypomorphic alleles of PCNA results in spontaneous DNA damage during S phase that elicits upregulation of ribonucleotide reductase (RNR) activity. Increased RNR activity leads to a dramatic...
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