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Article

NALP3: a key player in caspase-1 activation.

Journal of endotoxin research - 1 Jan 2006

Sutterwala Fayyaz S, Ogura Yasunori, Zamboni Dario S, Roy Craig R, Flavell Richard A

Abstract excerpt

The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases. Mutations in the NALP3/CIAS1/cryopyrin gene, a member of the NLR family, are linked to three auto-inflammatory disorders: Muckle-Wells syndrome, familial...

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Identifiers

PMID: 16953978
DOI: 10.1177/09680519060120040701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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NALP3: a key player in caspase-1 activation.PMID 16953978Read ↗

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