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Article

The NLRP3 Inflammasome as a Pharmacological Target

21 Jul 2019

Abstract excerpt

NLRP3 is a cytosolic receptor member of the nucleotide-binding oligomerization domain NOD-like receptor family that surveys the intracellular environment for the presence of infection, pathogens, and metabolic alarms. Although the surveillance activity of NLRP3 is required to protect the host from several pathogens, uncontrolled activity can be detrimental to the host. Pharmacological and genetic strategies...

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PMID: 31335445
DOI: 10.1097/fjc.0000000000000718

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