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Article

Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis

24 Nov 2022

Abstract excerpt

Background and Objectives Observational studies suggest low levels of 25-hydroxyvitamin D (25[OH]D) may be associated with increased disease activity in people with multiple sclerosis (PwMS). Large-scale genome-wide association studies (GWAS) suggest 25(OH)D levels are partly genetically determined. The resultant polygenic scores (PGSs) could serve as a proxy for 25(OH)D levels, minimizing potential confounding...

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PMID: 36418179
DOI: 10.1212/nxi.0000000000200062

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