Article
Genetic Prognostic Factors in Multiple Sclerosis: Key Discoveries and Unmet Needs.
International journal of molecular sciences - 17 Apr 2026
Ciampana Valentina, Virgilio Eleonora, Paciolla Loredana, Asaro Sofia, Franceschini Alessandro, Thavamani Muralidharan, Mazzini Letizia, Comi Cristoforo, Barizzone Nadia, D'Alfonso Sandra, Vecchio Domizia
Abstract excerpt
Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease characterized by marked clinical heterogeneity. While the genetic architecture underlying disease susceptibility is well established, the role of genetic factors in shaping disease prognosis remains clearly defined. In this structured narrative review, we examine available evidence on genetic contribution to key MS prognostic domains....
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