Article
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
The Lancet. Neurology - 1 Dec 2009
De Jager Philip L, Chibnik Lori B, Cui Jing, Reischl Joachim, Lehr Stephan, Simon K Claire, Aubin Cristin, Bauer David, Heubach Jürgen F, Sandbrink Rupert, Tyblova Michaela, Lelkova Petra, Havrdova Eva, Pohl Christoph, Horakova Dana, Ascherio Alberto, Hafler David A, Karlson Elizabeth W
Abstract excerpt
BACKGROUND: Prediction of susceptibility to multiple sclerosis (MS) might have important clinical applications, either as part of a diagnostic algorithm or as a means to identify high-risk individuals for prospective studies. We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are...
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