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The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease.

Translational psychiatry - 22 Dec 2022

Huang Jinghan, Tao Qiushan, Ang Ting Fang Alvin, Farrell John, Zhu Congcong, Wang Yixuan, Stein Thor D, Lunetta Kathryn L, Massaro Joseph, Mez Jesse, Au Rhoda, Farrer Lindsay A, Qiu Wei Qiao, Zhang Xiaoling

Abstract excerpt

Apolipoprotein ε4 (APOE ε4) is the most significant genetic risk factor for late-onset Alzheimer's disease (AD). Elevated blood C-reactive protein (CRP) further increases the risk of AD for people carrying the APOE ε4 allele. We hypothesized that CRP, as a key inflammatory element, could modulate the impact of other genetic variants on AD risk. We selected ten single nucleotide polymorphisms (SNPs) in reported AD...

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Identifiers

PMID: 36550123
DOI: 10.1038/s41398-022-02281-6
PMCID: PMC9780312

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