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Article

Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.

JCO precision oncology - 1 Mar 2022

Gularte-Mérida Rodrigo, Smith Shaleigh, Bowman Anita S, da Cruz Paula Arnaud, Chatila Walid, Bielski Craig M, Vyas Monika, Borsu Laetitia, Zehir Ahmet, Martelotto Luciano G, Shia Jinru, Yaeger Rona, Fang Fang, Gardner Rui, Luo Ruibang, Schatz Michael C, Shen Ronglai, Weigelt Britta, Sánchez-Vega Francisco, Reis-Filho Jorge S, Hechtman Jaclyn F

Abstract excerpt

PURPOSE: Mitogen-activated protein kinase pathway-activating mutations occur in the majority of colorectal cancer (CRC) cases and show mutual exclusivity. We identified 47 epidermal growth factor receptor/BRAF inhibitor-naive CRC patients with dual RAS hotspot/BRAF V600E mutations (CRC-DD) from a cohort of 4,561 CRC patients with clinical next-generation sequencing results. We aimed to define the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35235413
DOI: 10.1200/PO.21.00365
PMCID: PMC8906458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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