Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Feb 2021

Poulsen Tim Svenstrup, de Oliveira Douglas Vinicius Nogueira Perez, Espersen Maiken Lise Marcker, Klarskov Louise Laurberg, Skovrider-Ruminski Wojciech, Hogdall Estrid

Abstract excerpt

The MAPK signalling genes KRAS, NRAS and BRAF and the PIK3CA gene are routinely investigated for mutations in the diagnostic routine of colorectal cancer. Few studies have reported co-existing mutations in these genes with clinical relevance, while some have been previously regarded as mutually exclusive. We set to investigate the frequency and co-occurrent mutations in these targets, and the occurrence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Denmark

Share to DNA Mismatch Repair

Share to High-Throughput Nucleotide Sequencing

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 33075161
DOI: 10.1111/apm.13091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients.PMID 33075161Read ↗

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read ↗

BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.Semantic proximity Read ↗

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer.Semantic proximity Read ↗

Clinical characteristics of patients with colorectal cancer with double somatic mismatch repair mutations compared with Lynch syndromeSemantic proximity Read ↗

Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processesSemantic proximity Read ↗

Mismatch Repair Deficiency in Colorectal Adenocarcinoma: Clinical, Pathological and Prognostic Features, a Single Center’s Experience of 1002 CasesSemantic proximity Read ↗

Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential.Semantic proximity Read ↗

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.Semantic proximity Read ↗

Comprehensive Analysis of Oncogenic Fusions in Mismatch Repair Deficient Colorectal Carcinomas by Sequential DNA and RNA Next Generation SequencingSemantic proximity Read ↗

Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas.Semantic proximity Read ↗

Characteristics of colorectal carcinoma patients with PMS2 defects detected by immunohistochemistrySemantic proximity Read ↗

Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.