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Article

KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.

International journal of molecular sciences - 2 Mar 2023

Martianov Aleksandr S, Mitiushkina Natalia V, Ershova Anastasia N, Martynenko Darya E, Bubnov Mikhail G, Amankwah Priscilla, Yanus Grigory A, Aleksakhina Svetlana N, Tiurin Vladislav I, Venina Aigul R, Anuskina Aleksandra A, Gorgul Yuliy A, Shestakova Anna D, Maidin Mikhail A, Belyaev Alexey M, Baboshkina Liliya S, Iyevleva Aglaya G, Imyanitov Evgeny N

Abstract excerpt

This study aimed to analyze clinical and regional factors influencing the distribution of actionable genetic alterations in a large consecutive series of colorectal carcinomas (CRCs). KRAS, NRAS and BRAF mutations, HER2 amplification and overexpression, and microsatellite instability (MSI) were tested in 8355 CRC samples. KRAS mutations were detected in 4137/8355 (49.5%) CRCs, with 3913 belonging to 10 common...

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Identifiers

PMID: 36902296
DOI: 10.3390/ijms24054868
PMCID: PMC10003572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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