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Article

Variant-Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs.

International journal of cancer - 1 Oct 2026

Vaeyens Freya, Hetzel Jan-Patrick, Abdullah Khaldoon, Eggermont Carolien, Olsen Catharina, Mernberger Marco, Maes Ken, Vlaeminck Jelle, Claus Rainer, Vanisterbecq Dries, Hes Frederik, Pichler Martin, Giron Philippe, Timofeev Oleg, Noeparast Maxim

Abstract excerpt

Mutual exclusivity (ME) and co-occurrence (CO) of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant-level patterns. We performed a comprehensive, cross-cohort analysis of BRAF, KRAS, and EGFR mutation subtypes using 64,807 cBioPortal tumor samples, 1570 cancer cell lines, and 2714 Belgian clinical cases. Across all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 42253180
DOI: 10.1002/ijc.70558
PMCID: PMC13432369

Genes

EGFR
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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