Article
Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.
Molecular oncology - 1 Sept 2017
Dienstmann Rodrigo, Elez Elena, Argiles Guillem, Matos Ignacio, Sanz-Garcia Enrique, Ortiz Carolina, Macarulla Teresa, Capdevila Jaume, Alsina Maria, Sauri Tamara, Verdaguer Helena, Vilaro Marta, Ruiz-Pace Fiorella, Viaplana Cristina, Garcia Ariadna, Landolfi Stefania, Palmer Hector G, Nuciforo Paolo, Rodon Jordi, Vivancos Ana, Tabernero Josep
Abstract excerpt
Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the 'mutation dose') of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We performed a comprehensive analysis of MAFs of driver alterations in unpaired primary and metastatic colorectal cancer (CRC) at our institution from 2010 to 2015 and studied...
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