Article
Novel molecular insights from routine genotyping of colorectal carcinomas.
Human pathology - 1 Apr 2015
Stachler Matthew D, Rinehart Elizabeth, Lindeman Neal, Odze Robert, Srivastava Amitabh
Abstract excerpt
Routine tumor genotyping enables identification of concurrent mutations in tumors and reveals low-frequency mutations that may be associated with a particular tumor phenotype. We genotyped 311 colorectal carcinomas (CRCs) for 471 mutation hot spots in 41 cancer-associated genes. At least 1 mutation was present in 239 (77%) of 311 tumors. Two concurrent mutations were identified in 89 (29%) tumors, 3 mutations in...
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