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Article

Novel IL1RAP mutation associated with schizophrenia interferes with neuronal growth and related NF-κB signal pathways.

Neuroscience letters - 1 Apr 2022

Cheng Peipei, Zhang Ran, Shan Shifang, Yuan Bo, Chen Jinlong, Qiu Zilong, Du Yasong

Abstract excerpt

Schizophrenia is a complex, severe psychiatric disorder with a high heritability that affects approximately 1% of the world's population. Numerous schizophrenia-related risk genes have been reported in large-scale studies, but the role of most genetic abnormalities in the pathogenesis of the disease is still obscure. In this study, using whole-exome sequencing, we identified a novel nonsense mutation c.1324C > T...

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PMID: 35181481
DOI: 10.1016/j.neulet.2022.136533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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