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Article

A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation.

Current biology : CB - 26 Jan 2010

Pavlowsky Alice, Gianfelice Antonella, Pallotto Marta, Zanchi Alice, Vara Hugo, Khelfaoui Malik, Valnegri Pamela, Rezai Xavier, Bassani Silvia, Brambilla Dario, Kumpost Jiri, Blahos Jaroslav, Roux Michel J, Humeau Yann, Chelly Jamel, Passafaro Maria, Giustetto Maurizio, Billuart Pierre, Sala Carlo

Abstract excerpt

BACKGROUND: Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) gene mutations are associated with cognitive impairment ranging from nonsyndromic X-linked mental retardation to autism. IL1RAPL1 belongs to a novel family of Toll/IL-1 receptors, whose expression in the brain is upregulated b...

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Identifiers

PMID: 20096586
DOI: 10.1016/j.cub.2009.12.030

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20096586-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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