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Article

Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.

Molecular brain - 14 Jan 2021

Dong Fengping, Mao Joseph, Chen Miranda, Yoon Joy, Mao Yingwei

Abstract excerpt

Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population. Among the top genetic associations, zinc finger protein 804A (ZNF804A) gene encodes a zinc finger protein, associated with SZ and biolar disorder (BD). Copy number variants (CNVs) of ZNF804A have been observed in patients with autism spectrum disorders (ASDs), anxiety disorder, and BD, suggesting that ZNF804A is a dosage...

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Identifiers

PMID: 33446247
DOI: 10.1186/s13041-021-00729-2
PMCID: PMC7809827

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