Article
Variants of the RELA gene are associated with schizophrenia and their startle responses.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2011
Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Takahashi Hidetoshi, Iwase Masao, Okochi Tomo, Kazui Hiroaki, Saitoh Osamu, Tatsumi Masahiko, Iwata Nakao, Ozaki Norio, Kamijima Kunitoshi, Kunugi Hiroshi, Takeda Masatoshi
Abstract excerpt
The pathogenesis of schizophrenia is thought to involve aberrant immune and inflammatory responses. Nuclear factor kappa B (NF-κB) has important roles in the immune and inflammatory responses. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-κB complex. We genotyped four single-nucleotide polymorphisms (SNPs) in the RELA gene and performed a...
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