Article
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2013
Takao Keizo, Kobayashi Katsunori, Hagihara Hideo, Ohira Koji, Shoji Hirotaka, Hattori Satoko, Koshimizu Hisatsugu, Umemori Juzoh, Toyama Keiko, Nakamura Hironori K, Kuroiwa Mahomi, Maeda Jun, Atsuzawa Kimie, Esaki Kayoko, Yamaguchi Shun, Furuya Shigeki, Takagi Tsuyoshi, Walton Noah M, Hayashi Nobuhiro, Suzuki Hidenori, Higuchi Makoto, Usuda Nobuteru, Suhara Tetsuya, Nishi Akinori, Matsumoto Mitsuyuki, Ishii Shunsuke, Miyakawa Tsuyoshi
Abstract excerpt
Schnurri-2 (Shn-2), an nuclear factor-κB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which have been shown to harbor common variant single-nucleotide polymorphisms associated with schizophrenia. Although genes related to immunity are implicated in schizophrenia, there has been no study showing that their mutation or knockout...
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