Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes.

doi:10.1186/s12974-024-03320-3

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Article

Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes.

Journal of neuroinflammation - 18 Dec 2024

Ballasch Iván, López-Molina Laura, Galán-Ganga Marcos, Sancho-Balsells Anna, Rodríguez-Navarro Irene, Borràs-Pernas Sara, Rabadan M Angeles, Chen Wanqi, Pastó-Pellicer Carlota, Flotta Francesca, Maoyu Wang, Fernández-Irigoyen Joaquín, Santamaría Enrique, Aguilar Ruth, Dobaño Carlota, Egri Natalia, Hernandez Carla, Alfonso Miqueu, Juan Manel, Alberch Jordi, Del Toro Daniel, Arranz Belén, Canals Josep M, Giralt Albert

Abstract excerpt

Schizophrenia is a complex multifactorial disorder and increasing evidence suggests the involvement of immune dysregulations in its pathogenesis. We observed that IKZF1 and IKZF2, classic immune-related transcription factors (TFs), were both downregulated in patients' peripheral blood mononuclear cells (PBMCs) but not in their brain. We generated a new mutant mouse model with a reduction in Ikzf1 and Ikzf2 to...

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PMID: 39695786
DOI: 10.1186/s12974-024-03320-3
PMCID: PMC11658472

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