Article
Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression.
BMC cancer - 17 Feb 2022
Cloud Ashley S, Vargheese Aditya M, Gunewardena Sumedha, Shimak Raeann M, Ganeshkumar Sornakala, Kumaraswamy Easwari, Jensen Roy A, Chennathukuzhi Vargheese M
Abstract excerpt
BACKGROUND: Breast cancer is the most common malignancy in women, and is both pathologically and genetically heterogeneous, making early detection and treatment difficult. A subset of breast cancers express normal levels of REST (repressor element 1 silencing transcription factor) mRNA but lack functional REST protein. Loss of REST function is seen in ~ 20% of breast cancers and is associated with a more...
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