Article

miR-489 Confines Uncontrolled Estrogen Signaling Through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer

2022-01-05

Abstract excerpt

<h4>Background: </h4> Approximately 75% of diagnosed breast cancer tumors are estrogen-receptor (ER) positive tumors and are associated with better prognosis due to their response to hormonal therapies. However, around 40% of patients relapse after hormonal therapies. In the current study, we aim to evaluate miR-489 as a novel molecular target to combat tamoxifen resistance. <h4>Methods:</h4> Genomic analysis of g...

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Literature Corpus work: 0a2f446d-d4a3-5552-8aca-e476399008f3
DOI: 10.21203/rs.3.rs-131460/v2

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