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Article

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer

24 Oct 2013

Abstract excerpt

The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that are not fully understood. We identified the repressor element (RE)-1 silencing transcription factor (REST) as a mediator of AR actions on gene repression. Chromatin immunoprecipitation showed that AR binds chromatin regions containing well-characterized cis-elements known to mediate REST transcriptional repression, while...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 24163104
DOI: 10.1093/nar/gkt921

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