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Article

Tumor suppressor SET9 guides the epigenetic plasticity of breast cancer cells and serves as an early-stage biomarker for predicting metastasis.

Oncogene - 24 Nov 2016

Montenegro M F, Sánchez-Del-Campo L, González-Guerrero R, Martínez-Barba E, Piñero-Madrona A, Cabezas-Herrera J, Rodríguez-López J N

Abstract excerpt

During the course of cancer progression, neoplastic cells undergo dynamic and reversible transitions between multiple phenotypic states, and this plasticity is enabled by underlying shifts in epigenetic regulation. Our results identified a negative feedback loop in which SET9 controls DNA methyltransferase-1 protein stability, which represses the transcriptional activity of the SET9 promoter in coordination with...

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Identifiers

PMID: 27132511
DOI: 10.1038/onc.2016.154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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