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Article

Demethylation of Repressor Element-1 Silencing Transcription (REST) Suppresses the Malignant Phenotype of Breast Cancer via MMP9.

Oncology research - 13 Mar 2017

Liu Ying, Lv Hui, Wu Xiaoying, Zhou Jun, Shi Ying, Wen Jifang

Abstract excerpt

Breast cancer is the leading cause of cancer deaths in females all over the world, mainly resulting from metastasis. Previous studies have revealed that repressor element-1 (RE-1) silencing transcription (REST) acted as a tumor suppressor in breast cancer. However, the mechanism by which REST is regulated remains unknown, and its role in the metastasis in breast cancer cells remains unclear. In the present study,...

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Share to Apoptosis
Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Matrix Metalloproteinase 9

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Source

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Identifiers

PMID: 27697091
DOI: 10.3727/096504016X14747368729786
PMCID: PMC7841195

Genes

REST
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Demethylation of Repressor Element-1 Silencing Transcription (REST) Suppresses the Malignant Phenotype of Breast Cancer via MMP9.PMID 27697091Read ↗

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KLF9 inhibits breast cancer metastasis by up-regulating E-cadherinSemantic proximity Read ↗

Low REST Expression Indicates a Biomarker of Poor Prognosis in Patients with Renal Cell Carcinoma.Semantic proximity Read ↗

DNMT1 facilitates proliferation and metastasis of breast cancer by inducing MEG3 promoter methylation in MEG3/miR-494-3p/OTUD4 regulatory axisSemantic proximity Read ↗

Genome-wide assessment of REST binding profiles reveals distinctions between human and mouse hippocampusSemantic proximity Read ↗

Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashionSemantic proximity Read ↗

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancerSemantic proximity Read ↗

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