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GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.

Nucleic acids research - 1 Jul 2013

Li Mulin Jun, Wang Lily Yan, Xia Zhengyuan, Sham Pak Chung, Wang Junwen

Abstract excerpt

Interpreting the genetic variants located in the regulatory regions, such as enhancers and promoters, is an indispensable step to understand molecular mechanism of complex traits. Recent studies show that genetic variants detected by genome-wide association study (GWAS) are significantly enriched in the regulatory regions. Therefore, detecting, annotating and prioritizing of genetic variants affecting gene...

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Chromosomes, Human
Disease
Histones
Internet
Molecular Sequence Annotation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleotide Motifs

Regulatory Elements, Transcriptional

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PMID: 23723249
DOI: 10.1093/nar/gkt456
PMCID: PMC3692118

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