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Article

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.

Nature structural & molecular biology - 1 Feb 2022

Andreev Veselin I, Yu Changwei, Wang Juncheng, Schnabl Jakob, Tirian Laszlo, Gehre Maja, Handler Dominik, Duchek Peter, Novatchkova Maria, Baumgartner Lisa, Meixner Katharina, Sienski Grzegorz, Patel Dinshaw J, Brennecke Julius

Abstract excerpt

Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs are poorly understood. Here, we explain the mechanism by which the PIWI-interacting RNA (piRNA) pathway connects to the heterochromatin machinery in Drosophila. We find that...

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Identifiers

PMID: 35173350
DOI: 10.1038/s41594-022-00721-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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