Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease

23 Oct 2015

Abstract excerpt

Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial navigation, particularly grid cells, are impaired. Grid-cell-like representations in humans can be measured using functional magnetic resonance imaging. We found that young adults at genetic risk for AD (APOE-ε4 carriers) exhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Dementia and Cognitive Impairment Research
Share to Memory and Neural Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26494756
DOI: 10.1126/science.aac8128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s diseasePMID 26494756Read ↗

Unmasking selective path integration deficits in Alzheimer’s disease risk carriersSemantic proximity Read ↗

Disruption of the grid cell network in a mouse model of early Alzheimer’s diseaseSemantic proximity Read ↗

Functional connectivity between the entorhinal and posterior cingulate cortices associated with navigation impairment following path integration in at-genetic-risk Alzheimer’s diseaseSemantic proximity Read ↗

Functional neural signatures of navigation impairment in early Alzheimer’s DiseaseSemantic proximity Read ↗

Healthy versus Entorhinal Cortical Atrophy Identification in Asymptomatic APOE4 Carriers at Risk for Alzheimer's Disease.Semantic proximity Read ↗

No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer’s diseaseSemantic proximity Read ↗

Modeling the impact of genotype, age, sex, and continuous navigation on pathway integration performanceSemantic proximity Read ↗

Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease.Semantic proximity Read ↗

Genetic Alzheimer's Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields.Semantic proximity Read ↗

APOE2 Is Associated with Spatial Navigational Strategies and Increased Gray Matter in the HippocampusSemantic proximity Read ↗

Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentSemantic proximity Read ↗

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged <i> App <sup>NL-G-F</sup> </i> miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.