Article
Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease.
International journal of molecular sciences - 4 Feb 2022
Brandt Karim J, Burger Fabienne, Baptista Daniela, Roth Aline, Fernandes da Silva Rafaela, Montecucco Fabrizio, Mach Francois, Miteva Kapka
Abstract excerpt
(1) Background: Vascular smooth muscle cells (VSMCs) undergo a complex phenotypic switch in response to atherosclerosis environmental triggers, contributing to atherosclerosis disease progression. However, the complex heterogeneity of VSMCs and how VSMC dedifferentiation affects human carotid artery disease (CAD) risk has not been clearly established. (2) Method: A single-cell RNA sequencing analysis of CD45-...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.