Article
Mitochondria act as a key regulatory factor in cancer progression: Current concepts on mutations, mitochondrial dynamics, and therapeutic approach.
Mutation research. Reviews in mutation research - 1 Jan 2000
Roy Sraddhya, Das Ananya, Bairagi Aparajita, Das Debangshi, Jha Ashna, Srivastava Amit Kumar, Chatterjee Nabanita
Abstract excerpt
The diversified impacts of mitochondrial function vs. dysfunction have been observed in almost all disease conditions including cancers. Mitochondria play crucial roles in cellular homeostasis and integrity, however, mitochondrial dysfunctions influenced by alterations in the mtDNA can disrupt cellular balance. Many external stimuli or cellular defects that cause cellular integrity abnormalities, also impact...
Topics
- Humans
- Neoplasms
- Mitochondria
- Mutation
- Mitochondrial Dynamics
- Disease Progression
- DNA, Mitochondrial
- Animals
- MicroRNAs