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Article

Multidimensional Functional Profiling of Human Neuropathogenic FOXG1 Alleles in Primary Cultures of Murine Pallial Precursors.

International journal of molecular sciences - 25 Jan 2022

Frisari Simone, Santo Manuela, Hosseini Ali, Manzati Matteo, Giugliano Michele, Mallamaci Antonello

Abstract excerpt

FOXG1 is an ancient transcription factor gene mastering telencephalic development. A number of distinct structural FOXG1 mutations lead to the "FOXG1 syndrome", a complex and heterogeneous neuropathological entity, for which no cure is presently available. Reconstruction of primary neurodevelopmental/physiological anomalies evoked by these mutations is an obvious pre-requisite for future, precision therapy of...

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PMID: 35163265
DOI: 10.3390/ijms23031343
PMCID: PMC8835715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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