Integrating molecular studies and clinical disease models to provide mechanistic insight into neurodevelopment: guidance from FOXG1 syndrome.

Abstract excerpt

Neurodevelopment relies on precise coordination across molecular, cellular, and circuit-level processes. Conventional studies into neurodevelopmental gene function are primarily guided by tissue- or cell-type-specific expression patterns and inherent protein properties or domain interactions. Consideration of human disease conditions can greatly enhance our understanding of the mechanics underlying forebrain...

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