Article

Mitochondrial Dysfunction and Neuronal Anomalies in <i>POLG</i> Mutant Midbrain Organoids

2023-09-27

Abstract excerpt

Human pluripotent stem cell-derived midbrain organoids offer transformative potential for elucidating brain development, disease representation, and therapeutic innovations. We introduce a novel methodology to generate midbrain-specific organoids from both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). By employing tailored differentiation cues, notably dual-SMAD inhibition combined with F...

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Literature Corpus work: d3ab3413-5bb4-572d-97ed-7a2a35f33fa3
DOI: 10.1101/2023.09.27.559684

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