Article

Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium

2025-11-18

Abstract excerpt

Human brain development begins with the formation of the neural tube, a neuroepithelium organized around a single continuous lumen that is patterned to specify distinct brain regions. Human pluripotent stem cell (hPSC)-derived neural organoids offer powerful models to study this process and its disruption in disease. However, most existing protocols rely on stochastic self-organization of hPSC aggregates, leading...

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Literature Corpus work: ffc8b24e-7898-52c5-b90f-0863b10f68da
DOI: 10.1101/2025.11.18.689013

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