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Article

Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age

26 May 2010

Abstract excerpt

Cbl was originally discovered in 1989 as the cellular homolog of the v-Cbl oncogene, the transforming gene of the Cas NS-1 murine retrovirus that causes myeloid leukemia and lymphomas in mice. Cbl is a member of a family of RING finger ubiquitin ligases that negatively regulate signaling by tyrosine kinases and that function as adaptor proteins to regulate signaling positively. Until the past 2 years, there was...

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PMID: 20501843
DOI: 10.1158/0008-5472.can-10-0610

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