Article
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2010
Ogawa Seishi, Shih Lee-Yung, Suzuki Takahiro, Otsu Makoto, Nakauchi Hiromitsu, Koeffler H Phillip, Sanada Masashi
Abstract excerpt
c-CBL encodes a 120-kDa protein involved in intracellular signal transduction in a wide variety of cell types. Recently, frequent mutations of c-CBL have been reported in myeloid neoplasms showing both myelodysplastic and myeloproliferative features, in which most mutations are present in a homozygous state, as a result of allelic conversion in 11q. c-CBL has ubiquitin E3 ligase activity for a wide variety of...
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