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Article

Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

11 Feb 2022

Abstract excerpt

BACKGROUND: Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not been fully described in DMGs. METHODS: DMG models including primary human in vitro (n = 18) and in vivo (murine and zebrafish) models, and patient (n = 20) frozen and FFPE...

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PMID: 35157764
DOI: 10.1093/neuonc/noac041

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