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Article

Integrated analysis of mitochondrial ETC inhibition reveals genotype-specific heterogeneity of drug response in glioblastoma.

Biochemical and biophysical research communications - 1 Nov 2025

Belekar Madhuri, Kavatalkar Vijendra, Yadav Ritu, Raghunathan Anu

Abstract excerpt

Glioblastoma (GBM) is among the most aggressive brain cancers, driven by genetic diversity and resistance to therapy. Mitochondrial metabolism-and in particular the electron transport chain (ETC)-has emerged as both a key weakness and a source of variable drug response. To investigate this, we integrated constraint-based metabolic modeling (CBM), high-resolution drug profiling, and genomic sequencing across three...

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PMID: 41101241
DOI: 10.1016/j.bbrc.2025.152798

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