Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations

Abstract excerpt

Diffuse Midline Gliomas (DMGs) are universally fatal, primarily pediatric malignancies affecting the midline structures of the central nervous system. Despite decades of clinical trials, treatment remains limited to palliative radiation therapy. A major challenge is the coexistence of molecularly distinct malignant cell states with potentially orthogonal drug sensitivities. To address this challenge, we leveraged...

Topics

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• Epigenetics and DNA Methylation
• FOXO transcription factor regulation
• Glioma Diagnosis and Treatment
• Histone Deacetylase Inhibitors Research
• Neuroblastoma Research and Treatments
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

1cd5c8e7-3288-5b28-a128-78845e329377

DOI

10.1101/2024.03.17.585370