Article

ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma

2025-09-29

Abstract excerpt

<h4>Background</h4> Medulloblastoma is the most common malignant pediatric brain tumor, and has an urgent need for novel treatment approaches. Dordaviprone (ONC201) and its chemical derivative with nanomolar potency, ONC206, induce apoptosis of cancer cells by activation of the mitochondrial caseinolytic protease P (ClpP). ONC206 is currently in Phase I clinical trials for pediatric patients with primary brain tu...

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Literature Corpus work: 0262510d-8a8a-5e06-b8b8-6e9ef2906cb5
DOI: 10.1101/2025.09.25.678693

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