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A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

27 Aug 2024

Abstract excerpt

Glioma cells hijack developmental programs to control cell state. Here, we uncover a glioma cell state-specific metabolic liability that can be therapeutically targeted. To model cell conditions at brain tumor inception, we generated genetically engineered murine gliomas, with deletion of p53 alone (p53) or with constitutively active Notch signaling (N1IC), a pathway critical in controlling astrocyte...

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PMID: 39192032
DOI: 10.1038/s44318-024-00176-4

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