Article

Combination of Imipridone ONC201 or ONC206 with Temozolomide and Radiotherapy in triple ITR therapy reduces intracranial tumor burden and prolongs survival in an orthotopic wild-type IDH GBM mouse model

2024-09-27

Abstract excerpt

Glioblastoma remains the most lethal common primary brain tumor in adults with limited therapeutic options. TIC10/ONC201, a first-in-class imipridone we discovered, achieved meaningful therapeutic effects in phase I/II trials in patients with diffuse gliomas harboring H3K27M mutations, and currently the drug is in randomized phase III testing (ACTION trial; NCT05580562 ). ONC201 targets mitochondrial protease Clp...

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Literature Corpus work: 87194b48-e0e4-544a-85e8-030211a97182
DOI: 10.1101/2024.09.25.610187

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