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Article

Aberrant somatic hypermutation of CCND1 generates non-coding drivers of mantle cell lymphomagenesis.

Cancer gene therapy - 1 May 2022

Müller Heiko, Walter Wencke, Hutter Stephan, Nadarajah Niroshan, Meggendorfer Manja, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

Aberrant somatic hypermutation (aSHM) can target proto-oncogenes and drive oncogenesis. In mantle cell lymphoma (MCL), CCND1 is targeted by aSHM in the non-nodal subtype (nnMCL), giving rise to exon1 encoded mutant proteins like E36K, Y44D, and C47S that contribute to lymphomagenesis by virtue of their increased protein stability and nuclear localization. However, the vast majority of somatic variants generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35145272
DOI: 10.1038/s41417-022-00428-7
PMCID: PMC9113931

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