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Article

Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma.

Blood - 1 Aug 2006

Liso Arcangelo, Capello Daniela, Marafioti Teresa, Tiacci Enrico, Cerri Michaela, Distler Verena, Paulli Marco, Carbone Antonino, Delsol Georges, Campo Elias, Pileri Stefano, Pasqualucci Laura, Gaidano Gianluca, Falini Brunangelo

Abstract excerpt

Aberrant somatic hypermutation (SHM) has been identified as a mechanism for genomewide instability in diffuse large B-cell lymphoma (DLBCL). To assess whether aberrant SHM plays a role in the molecular pathogenesis of Hodgkin lymphoma (HL), we investigated microdissected neoplastic cells of nodular lymphocyte-predominant HL (NLPHL; n = 10) and classic HL (cHL; n = 9) for the presence of mutations in the 5'...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 16614247
DOI: 10.1182/blood-2005-10-3949

Genes

PAX5
MYC
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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