Article
Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
Blood - 30 Jul 2020
Pararajalingam Prasath, Coyle Krysta M, Arthur Sarah E, Thomas Nicole, Alcaide Miguel, Meissner Barbara, Boyle Merrill, Qureshi Quratulain, Grande Bruno M, Rushton Christopher, Slack Graham W, Mungall Andrew J, Tam Constantine S, Agarwal Rishu, Dawson Sarah-Jane, Lenz Georg, Balasubramanian Sriram, Gascoyne Randy D, Steidl Christian, Connors Joseph, Villa Diego, Audas Timothy E, Marra Marco A, Johnson Nathalie A, Scott David W, Morin Ryan D
Abstract excerpt
Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is incurable with standard therapies. The genetic drivers of this cancer have not been firmly established, and the features that contribute to differences in clinical course remain limited. To extend our understanding of the biological pathways involved in this malignancy, we performed a large-scale genomic analysis of MCL using data...
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