Article
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials.
Leukemia - 1 Dec 2024
Khouja Mouhamad, Jiang Linmiao, Pal Karol, Stewart Peter James, Regmi Binaya, Schwarz Martin, Klapper Wolfram, Alig Stefan K, Darzentas Nikos, Kluin-Nelemans Hanneke C, Hermine Olivier, Dreyling Martin, Gonzalez de Castro David, Hoster Eva, Pott Christiane
Abstract excerpt
Recent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patients from the European MCL network trials by targeted sequencing of peripheral blood DNA using the EuroClonality(EC)-NDC assay. The IGH::CCND1 fusion was identified in 94% of...
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